[Lfm] CDB SPECIAL SEMINAR 19th Nov - Lucy O'Brien, Stanford University - Cell dynamics of flexible organ states

[Nic Tapon]

Hi all,
UCL is hosting Lucy O’Brien for a seminar in November. Feel free to join by Teams on the link below.
Best,
Nic

When: 19 November 2020 5:00 PM-6:00 PM.
Where:


Following a poll of CDB graduate students a list of desirable speakers was drawn up and the students extended an invitation to Lucy O'Brien of Stanford University https://www.stemdynamics.org/lucy-obrien<https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.stemdynamics.org%2Flucy-obrien&data=02%7C01%7C%7C6a23027974014d23737b08d85956acc5%7C4eed7807ebad415aa7a99170947f4eae%7C0%7C0%7C637357576088140839&sdata=vk00f5NXNFPW7Trvx6P%2Bk0m2Q0GUjZxRGWyE7uQ5K1s%3D&reserved=0>



Hosts: Matthew Bostock & Tom Dufor



Title: Cell dynamics of flexible organ states



Abstract: Our organs contain multitudes of cells: Stem cells that generate new cells, new cells that are differentiating, differentiated cells that execute organ function, and dying cells that will soon be lost. What are the dynamics of this cellular life-cycle? How are cellular life-cycles coordinated at the organ-scale? How do they change in response to changing physiological demands? We explore these questions using the intestinal epithelium of the adult Drosophila midgut. The relative simplicity of this digestive organ--a tube comprising ~10,000 differentiated cells and ~2,000 stem cells--enables fine-grained analyses of population dynamics over space and time. By combining long-term, in vivo imaging with advanced genetic tools, we are investigating how cell numbers, fates, and organization are flexibly controlled at the tissue-scale. In my seminar, I will discuss recent insights into the homeostatic feedback signals that underlie cellular equilibrium and the spatiotemporal dynamics of cellular differentiation.
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The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT

The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT
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