From Lucy.Fea at crick.ac.uk Thu Jan 2 11:42:54 2025 From: Lucy.Fea at crick.ac.uk (Lucy Fea) Date: Thu, 2 Jan 2025 11:42:54 +0000 Subject: [Lfm] January LFM Message-ID: Dear all, Happy new year! The January LFM will be next week on Wednesday 8 January at 5.30pm. It will be a hybrid event (see zoom link below). If you are attending in person, please arrive between 5.15 and 5.30pm. You will first need to check in with the security desk near the seminar rooms, who will have your name on a guest list if you are subscribed to the LFM mailing list. Any attendees not subscribed will need to grab one of the Crick scientists who will be waiting at the entrance, and they will then help take you through security. Speakers: Carlos Estella: A cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila (Estella Lab, CBMSO Madrid (currently doing sabbatical with Vincent lab at the Crick)) Terrence Trinca: Leveraging the fly to reveal novel extravasation genes (Martin/Weaver lab, University of Bristol) Join Zoom Meeting https://crick.zoom.us/j/61083105852?pwd=aWjp01zbaR6wItZby2YIYARzuUeOie.1 Meeting ID: 610 8310 5852 Passcode: 416466 Send your new lab members here to sign up to the LFM mailing list: http://lists.londonflymeeting.org/listinfo/lfm Directions to the Crick: https://www.crick.ac.uk/about-us/visit-us The LFM is generously sponsored by the Genetics Society [Graphical user interface Description automatically generated with medium confidence] The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: not available Type: text/calendar Size: 3577 bytes Desc: not available URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: image001.png Type: image/png Size: 8356 bytes Desc: image001.png URL: From Lucy.Fea at crick.ac.uk Thu Jan 2 11:45:52 2025 From: Lucy.Fea at crick.ac.uk (Lucy Fea) Date: Thu, 2 Jan 2025 11:45:52 +0000 Subject: [Lfm] January LFM Message-ID: Dear all, Happy new year! The January LFM will be next week on Wednesday 8 January at 5.30pm. It will be a hybrid event (see zoom link below). If you are attending in person, please arrive between 5.15 and 5.30pm. You will first need to check in with the security desk near the seminar rooms, who will have your name on a guest list if you are subscribed to the LFM mailing list. Any attendees not subscribed will need to grab one of the Crick scientists who will be waiting at the entrance, and they will then help take you through security. Speakers: Carlos Estella: A cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila (Estella Lab, CBMSO Madrid (currently doing sabbatical with Vincent lab at the Crick)) Terrence Trinca: Leveraging the fly to reveal novel extravasation genes (Martin/Weaver lab, University of Bristol) Join Zoom Meeting https://crick.zoom.us/j/61083105852?pwd=aWjp01zbaR6wItZby2YIYARzuUeOie.1 Meeting ID: 610 8310 5852 Passcode: 416466 Send your new lab members here to sign up to the LFM mailing list: http://lists.londonflymeeting.org/listinfo/lfm Directions to the Crick: https://www.crick.ac.uk/about-us/visit-us The LFM is generously sponsored by the Genetics Society [Graphical user interface Description automatically generated with medium confidence] The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: not available Type: text/calendar Size: 3577 bytes Desc: not available URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: image001.png Type: image/png Size: 8356 bytes Desc: image001.png URL: From p.baptista-ribeiro at qmul.ac.uk Tue Jan 7 15:47:05 2025 From: p.baptista-ribeiro at qmul.ac.uk (Paulo Baptista-Ribeiro) Date: Tue, 7 Jan 2025 15:47:05 +0000 Subject: [Lfm] phospho-Akt antibody for Drosophila In-Reply-To: References: Message-ID: Dear LFMers, We are looking for a phospho-Akt antibody for Drosophila. We currently have a very small aliquot of a p-Akt antibody from CST (#4054; https://www.cellsignal.com/products/primary-antibodies/phospho-drosophila-akt-ser505-antibody/4054), which has been discontinued. The suggested replacement for the discontinued antibody is CST #4060 (https://www.cellsignal.com/products/primary-antibodies/phospho-akt-ser473-d9e-xp-rabbit-mab/4060), which is supposed to cross-react with the Drosophila protein in Western blots but we didn't see this in our hands. If anyone has or knows of an alternative p-Akt that works with Drosophila (ideally in both IF and WB), please let us know. Thank you very much for your help. All the best, Paulo ____________________________________________________________________________ Paulo S. Ribeiro Reader in Cell and Developmental Biology | Protein Dynamics and Cell Signalling Laboratory | Centre for Tumour Biology Barts Cancer Institute - Queen Mary University of London and part of the Cancer Research UK City of London Centre T: +44 (0)20 7882 3829 | E: p.baptista-ribeiro at qmul.ac.uk https://www.bci.qmul.ac.uk/ [cid:69389c53-995f-407e-af19-859d1c218f64] -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: Outlook-d1g01edc.png Type: image/png Size: 31985 bytes Desc: Outlook-d1g01edc.png URL: From m.dionne at imperial.ac.uk Tue Jan 7 16:57:50 2025 From: m.dionne at imperial.ac.uk (Dionne, Marc S) Date: Tue, 7 Jan 2025 16:57:50 +0000 Subject: [Lfm] phospho-Akt antibody for Drosophila In-Reply-To: References: Message-ID: <500B9E3D-B275-4953-AF7C-F58036B07186@ic.ac.uk> Hi Paulo (and all)? We?ve previously used D9E (the recommended substitution) on whole-fly westerns and gotten basically identical results to what we got with 4054. If D9E is now not working, I don?t know what we would use instead? Yours Marc > On 7 Jan 2025, at 15:47, Paulo Baptista-Ribeiro wrote: > > This email from p.baptista-ribeiro at qmul.ac.uk originates from outside Imperial. Do not click on links and attachments unless you recognise the sender. If you trust the sender, add them to your safe senders list to disable email stamping for this address. Dear LFMers, > > We are looking for a phospho-Akt antibody for Drosophila. We currently have a very small aliquot of a p-Akt antibody from CST (#4054;https://www.cellsignal.com/products/primary-antibodies/phospho-drosophila-akt-ser505-antibody/4054), which has been discontinued. > > The suggested replacement for the discontinued antibody is CST #4060 (https://www.cellsignal.com/products/primary-antibodies/phospho-akt-ser473-d9e-xp-rabbit-mab/4060), which is supposed to cross-react with the Drosophila protein in Western blots but we didn't see this in our hands. > > If anyone has or knows of an alternative p-Akt that works with Drosophila (ideally in both IF and WB), please let us know. > > Thank you very much for your help. > > All the best, > Paulo > > ____________________________________________________________________________ > Paulo S. Ribeiro > Reader in Cell and Developmental Biology | Protein Dynamics and Cell Signalling Laboratory | Centre for Tumour Biology > Barts Cancer Institute - Queen Mary University of London and part of the Cancer Research UK City of London Centre > T: +44 (0)20 7882 3829 | E: p.baptista-ribeiro at qmul.ac.uk > https://www.bci.qmul.ac.uk/ > > > ******************* > This email originates from outside Imperial. Do not click on links and attachments unless you recognise the sender. > If you trust the sender, add them to your safe senders list https://spam.ic.ac.uk/SpamConsole/Senders.aspx to disable email stamping for this address. > ******************* > _______________________________________________ > Lfm mailing list > Lfm at londonflymeeting.org > http://lists.londonflymeeting.org/listinfo/lfm -- Marc S Dionne, PhD Principal Investigator, Centre for Bacterial Resistance Biology Professor of Innate Immunity Department of Life Sciences Imperial College London South Kensington Campus G.23 Flowers Building London SW7 2AZ United Kingdom +44 20 7594 5776 http://www.imperial.ac.uk/people/m.dionne From Lucy.Fea at crick.ac.uk Wed Jan 8 10:08:42 2025 From: Lucy.Fea at crick.ac.uk (Lucy Fea) Date: Wed, 8 Jan 2025 10:08:42 +0000 Subject: [Lfm] January LFM - TODAY Message-ID: Dear all, A reminder that the January LFM is today at 5.30pm. It will be a hybrid event (see zoom link below). If you are attending in person, please arrive between 5.15 and 5.30pm. You will first need to check in with the security desk near the seminar rooms, who will have your name on a guest list if you are subscribed to the LFM mailing list. Any attendees not subscribed will need to grab one of the Crick scientists who will be waiting at the entrance, and they will then help take you through security. Speakers: Carlos Estella: A cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila (Estella Lab, CBMSO Madrid (currently doing sabbatical with Vincent lab at the Crick)) Terrence Trinca: Leveraging the fly to reveal novel extravasation genes (Martin/Weaver lab, University of Bristol) Join Zoom Meeting https://crick.zoom.us/j/61083105852?pwd=aWjp01zbaR6wItZby2YIYARzuUeOie.1 Meeting ID: 610 8310 5852 Passcode: 416466 Send your new lab members here to sign up to the LFM mailing list: http://lists.londonflymeeting.org/listinfo/lfm Directions to the Crick: https://www.crick.ac.uk/about-us/visit-us The LFM is generously sponsored by the Genetics Society [Graphical user interface Description automatically generated with medium confidence] The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT Lucy Fea Science Operations Coordinator The Francis Crick Institute 1 Midland Road London NW1 1AT T: 020 3796 5412 E: lucy.fea at crick.ac.uk Please note my working hours are: Mon: 10am to 5.30pm Tues: non-working day Weds: 9.30am to 5.30pm Thurs: 10am to 5.30pm Fri: non-working day The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: image001.png Type: image/png Size: 8356 bytes Desc: image001.png URL: From helena.cocheme at lms.mrc.ac.uk Fri Jan 10 11:43:34 2025 From: helena.cocheme at lms.mrc.ac.uk (Cocheme, Helena M) Date: Fri, 10 Jan 2025 11:43:34 +0000 Subject: [Lfm] New PI positions at MRC Laboratory of Medical Sciences (LMS) - deadline 13/01/2025 Message-ID: The MRC Laboratory of Medical Sciences (LMS) is recruiting for several new tenure-track PI positions. This is an exciting opportunity for ECRs to establish their own research group in London! Research with in vivo model systems (including Drosophila in our shiny new building and fly facilities!) is encouraged. The deadline is *Monday 13th January* (before midnight UK-time), so do apply if your profile fits the institute's scientific priority areas, in the translational context of multimorbidities & ageing: - sex differences in biology and disease - cell identity across the life course - gene-environment interactions Thanks in advance for helping to spread the word! Helena [52716358793_30d28fe7b0_o-scaled.jpg] Programme Leader Track - MRC Laboratory of Medical Sciences lms.mrc.ac.uk ? Dr Helena Cocheme (she/her) Group Head - Redox Metabolism MRC Laboratory of Medical Sciences (LMS) LMS Building Imperial College London, Hammersmith Hospital Campus Du Cane Road London W12 0HS helena.cocheme at lms.mrc.ac.uk www.cochemelab.org @CochemeLab My working day may not be the same as yours. I don?t expect a reply outside of your normal working hours. -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: 52716358793_30d28fe7b0_o-scaled.jpg Type: image/jpeg Size: 151451 bytes Desc: 52716358793_30d28fe7b0_o-scaled.jpg URL: From Nic.Tapon at crick.ac.uk Sun Jan 12 15:36:28 2025 From: Nic.Tapon at crick.ac.uk (Nicolas Tapon) Date: Sun, 12 Jan 2025 15:36:28 +0000 Subject: [Lfm] Fly cancer models virtual seminars Thursday Jan 30th Message-ID: Dear Drosophila cancer researcher- I?d like to call your attention to a virtual seminar series that the US National Cancer Institute (NCI) is holding on non-mammalian models of cancer. After years of advocacy to consider experimental systems including flies, fish and worms, NCI has invited several groups to present work and make the case for the value of these organisms in cancer biology. On Thursday Jan 30th from 1-2:15 PM (US EST), Norbert Perrimon, Wu-Min Deng and I will speak about our labs? research and the strengths and limitations of the fly as a model for cancer. I encourage you and your lab members to register for the webinar. Enthusiasm reflected by registrants and attendees may make a positive impression on NCI as they consider offering funding opportunities targeted to non-mammalian models. So a high turnout for our fly session in particular would provide important support for the field in which we all work. For overseas colleagues, fly cancer work in the US has been stymied by funding challenges that go beyond the familiar underappreciation of Drosophila research. Briefly, the structure of NIH institutes includes the National Institute of General Medical Sciences (NIGMS) which supports ?basic? research, as well as other institutes such as NCI that support disease-targeted research. NCI has historically not considered flies (or really any non-mammalian model) as relevant to cancer, so only a few fly grants have been funded over the last twenty years despite an enormous budget. However, NIGMS will not support cancer research (considering that the mission of NCI), so grants that mention cancer are often rerouted to NCI for review. So it has been nearly impossible to fund fly cancer research through the NIH. For US colleagues, I?d love to hear about any experiences that you have had in trying to get your own fly cancer work funded through the NIH. If possible, I will share these experiences with NCI program staff in hopes of shifting the culture both in the administration and in study sections. Thanks and I look forward to seeing you at either the San Diego or Alicante meetings this year. David Bilder The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT -------------- next part -------------- An HTML attachment was scrubbed... URL: