[Lfm] Postdoc position in the Brown lab

[Nic Tapon]

Hi All,

We have a postdoc position available in my lab, funded for three years to work on an exciting collaborative project focused on cell adhesion.
http://www.jobs.cam.ac.uk/job/20215/<https://emea01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.jobs.cam.ac.uk%2Fjob%2F20215%2F&data=02%7C01%7C%7Ca83e0474d8a54cb390e408d68c547e0e%7C4eed7807ebad415aa7a99170947f4eae%7C0%7C0%7C636850691864265582&sdata=F6hEmI2F1i%2BdGIpLaKccHweVmm77Z2nTMXosNbVgqaM%3D&reserved=0>
The closing date is 25th February, 2019, and it is available from 1st March.

Ben Goult (University of Kent) and I found that we both had initial data suggesting that the intracellular proteins working with integrin extracellular matrix receptors form a functional aggregate after they are unfolded by mechanical forces. This is one of a growing number of examples where protein aggregation is used in a positive way, for example as seen in the process of memory formation, and contrasts with the deterimental aggregates linked to dementia. The postdoc in my lab will test the importance of self-interactions in integrin function within the fly, to complement biochemical and structural work on the formation and structure of the aggregate's performed by the postdoc in Ben's lab. The project involves extensive gene-editing followed by phenotypic analysis by advanced microscopy, so experience in molecular biology, fly genetics and development and microscopy will all be useful. Please feel free to contact me if you want more information.

Please pass on to anyone you think might be interested.

Many thanks, Nick

--
Nick Brown
Professor of Cell Biology
PI, FlyBase
Dept of Physiology, Development
and Neuroscience
University of Cambridge
Downing St
Cambridge CB2 3DY


The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT
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