[Lfm] FW: CARD seminar series: 13th Feb Greg Neely

[Baron, Olga]

Dear all,

Greg Neely from Sydney, Australia, will be visiting us next Wednesday. Greg is using an integrative approach of Drosophila genetics and hiPSCs to understand evolutionary conserved mechanisms important for chronic pain.

Please let me know if you would like to talk to Greg before or later after the seminar.

Best wishes,
Olga

______________________
Dr Olga Baron
NC3R David Sainsbury Fellow
https://www.nc3rs.org.uk/meet-our-david-sainsbury-fellows
King's College London
Institute of Psychiatry, Psychology & Neuroscience
Wolfson CARD
Wolfson Wing, Hodgkin Building, WW 3.24
Guy's Campus
London
SE1 1UL


phone
office: +44(0)20 7848 8144
mobile: +44 (0)7599 821082



________________________________
From: Bannister, Kirsty
Sent: 07 February 2019 13:43
To: ML-WCARD-all
Cc: cdn-all Mailman List
Subject: CARD seminar series: 13th Feb Greg Neely

Wolfson CARD seminar

Wednesday 13th of February 12:00, Wolfson CARD Seminar Room, Wolfson Wing, Hodgkin Building

Speaker: Professor Gregg Neely

Title: Loss of central inhibition leads to neuropathic pain in Drosophila

Greg Neely is Associate Professor at the Charles Perkins Center of the University of Sydney. A continuing interest of Greg's lab is high throughput phenotypic screening using fruit flies or cell culture systems, and a major focus is using these tools to find new genes and mechanisms that control pain perception or chronic pain.

https://www.neelylab.com/<https://emea01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.neelylab.com%2F&data=01%7C01%7Colga.baron%40kcl.ac.uk%7Cf60c04b270a54976b70b08d68d024a18%7C8370cf1416f34c16b83c724071654356%7C0&sdata=%2FRMq4m3Sf%2Bgyy8se8llR6BEOAAdYrJJWKIxYgC89wzc%3D&reserved=0>

Abstract

Nerve injury can lead to devastating pain that is difficult to treat, in part because we have an incomplete understanding of the biology driving disease. To identify core disease mechanisms we investigated neuropathic pain in Drosophila. We show that peripheral injury triggers a loss of central inhibition which was necessary and sufficient to develop neuropathic sensitization. Similar changes in central inhibitory tone have been described in mammalian pain and this may represent a core disease pathology that is amenable to therapy. To this end, we generated inhibitory neurons derived from human induced pluripotent stem cells (hiPSC) and transplanted these neurons into the spinal cord of neuropathic mice. Remarkably, hiPSC-derived inhibitory transplants survive long-term, show integration, and promoted lasting pain relief without side effects. Together, these data highlight that central disinhibition is a core mechanism driving neuropathic pain, and argue that hiPSC-derived transplants may be an effective and non-addictive pain therapy.

Hosts: Stephen McMahon and Olga Baron

If you wish to speak to Greg, please email to olga.baron at kcl.ac.uk<mailto:olga.baron at kcl.ac.uk>

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